I don't have info on the "nursery", but according to Andre Maurois's
"A History of France", (1968 U.S. edition, page 132) Henry II
complained that he was badly treated by the Spanish. Henry and his
brother were held hostage as a result of a treaty his father, Francis
I, negotiated while imprisoned in Spain. In exchange for his freedom
Francis agreed to allow the Emporer the Duchy of Burgundy. Henry and
his brother were held as hostages to guarantee the agreement. But
after Francis I's release, the Burgundians refused to become part of
the Empire. So Henry's grandmother, Louise of Savoy, and the
Emporer's sister, Archduchess Margaret negotiated in 1529 "The Ladies
Peace" (The Peace of Cambrai) which set the ransom for the freedom of
the two princes at two million gold ecus, which the French paid.
There was obviously bad blood between the Valois and Habsburgs. One
clause in the Cambrai treaty required Francis I to marry the Emporer's
sister, Eleanor, which the King did in 1530. Under the circumstance
this proved to be an unhappy marriage.
Maurois writes that as king, Henry II of France, due to the bad
treatment he received during his childhood captivity, hated the
Spanish and especially Charles V.